Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 42

  1. Cat.No. Product Name Information/Activity
  2. BCN5339 Quetiapine fumarate Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. Quetiapine fumarate chemical structure
  3. BCC3850 Risperidone Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively. Risperidone chemical structure
  4. BCC6790 (+)-UH 232 maleate 1217473-50-1 (+)-UH 232 maleate chemical structure
  5. BCC2072 Ziprasidone hydrochloride monohydrate Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. Ziprasidone hydrochloride monohydrate chemical structure
  6. BCC7838 Zotepine 26615-21-4 Zotepine chemical structure
  7. BCC6353 PAOPA 114200-31-6 PAOPA chemical structure
  8. BCC6756 7-Hydroxy-DPAT hydrobromide 76135-30-3 7-Hydroxy-DPAT hydrobromide chemical structure
  9. BCC6760 7-Hydroxy-PIPAT maleate 200722-46-9 7-Hydroxy-PIPAT maleate chemical structure
  10. BCN2181 Pramipexole dihydrochloride Pramipexole dihydrochloride is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. Pramipexole dihydrochloride chemical structure
  11. BCC7193 Eticlopride hydrochloride 97612-24-3 Eticlopride hydrochloride chemical structure

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