Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 59

  1. Cat.No. Product Name Information/Activity
  2. BCC6816 Chicago Sky Blue 6B 2610-05-1 Chicago Sky Blue 6B chemical structure
  3. BCC6556 Dihydrokainic acid 52497-36-6 Dihydrokainic acid chemical structure
  4. BCC7295 (±)-HIP-B 227619-65-0 (±)-HIP-B chemical structure
  5. BCC6565 L-(-)-threo-3-Hydroxyaspartic acid 7298-99-9 L-(-)-threo-3-Hydroxyaspartic acid chemical structure
  6. BCC6804 (±)-threo-3-Methylglutamic acid 63088-04-0 (±)-threo-3-Methylglutamic acid chemical structure
  7. BCC6873 MPDC MPDC is a potent and competitive inhibitor of the Na+-dependent high-affinity glutamate transporter in forebrain synaptosomes. MPDC chemical structure
  8. BCC6595 L-trans-2,4-PDC 64769-66-0 L-trans-2,4-PDC chemical structure
  9. BCC5735 DL-TBOA DL-TBOA is a potent non-transportable inhibitor of excitatory amino acid transporters with IC50s of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter-1 (EAAT1), EAAT2 and EAAT3, respectively. DL-TBOA inhibits the uptake of [14C]glutamate in COS-1 cells expressing the human EAAT1 and EAAT2 with Ki valuesof 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA chemical structure
  10. BCC5919 TFB-TBOA 480439-73-4 TFB-TBOA chemical structure
  11. BCC7692 UCPH 101 UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. UCPH 101 chemical structure

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