Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 63

  1. Cat.No. Product Name Information/Activity
  2. BCC7137 [bAla8]-Neurokinin A(4-10) [bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist. [bAla8]-Neurokinin A(4-10) chemical structure
  3. BCC5994 [Lys5,MeLeu9,Nle10]-NKA(4-10) 137565-28-7 [Lys5,MeLeu9,Nle10]-NKA(4-10) chemical structure
  4. BCC7001 GR 159897 GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK2) receptor antagonist. GR 159897 has little or no affinity for NK1 and NK3 receptors. GR 159897 inhibits binding of [3H]GR100679 to human NK2 (hNK2)-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects. GR 159897 chemical structure
  5. BCC5799 GR 94800 141636-65-9 GR 94800 chemical structure
  6. BCC5729 MDL 29,913 135721-56-1 MDL 29,913 chemical structure
  7. BCC7133 MEN 10376 Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a Ki of 4.4 μM for rat small intestine NK-2 receptor. MEN 10376 chemical structure
  8. BCC6921 Senktide Senktide is a tachykinin NK3 receptor agonist. Senktide chemical structure
  9. BCC7037 SB 218795 174635-53-1 SB 218795 chemical structure
  10. BCC1926 SB-222200 SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier. SB-222200 chemical structure
  11. BCC1981 Talnetant Talnetant (SB 223412) is a potent and selective NK3 receptor antagonist (ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM. Talnetant chemical structure

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