Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 51

  1. Cat.No. Product Name Information/Activity
  2. BCC6872 CPPG CPPG ((RS)-CPPG) is a potent group II/III mGlu receptor antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors. CPPG chemical structure
  3. BCC7528 MMPIP hydrochloride 479077-02-6 MMPIP hydrochloride chemical structure
  4. BCC6818 MPPG 169209-65-8 MPPG chemical structure
  5. BCC7033 UBP1112 339526-74-8 UBP1112 chemical structure
  6. BCC6150 TC-N 22A 1314140-00-5 TC-N 22A chemical structure
  7. BCC7901 TCN 238 TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. TCN 238 chemical structure
  8. BCC4596 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU 0361737 chemical structure
  9. BCC1239 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. VU 0364439 chemical structure
  10. BCC4597 VU 0364770 VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively. VU 0364770 chemical structure
  11. BCC7925 Bicifadine hydrochloride 66504-75-4 Bicifadine hydrochloride chemical structure

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