Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 58

  1. Cat.No. Product Name Information/Activity
  2. BCC6574 Guvacine hydrochloride Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine hydrochloride chemical structure
  3. BCC6576 (±)-Nipecotic acid 60252-41-7 (±)-Nipecotic acid chemical structure
  4. BCC7472 NNC 05-2090 hydrochloride 184845-18-9 NNC 05-2090 hydrochloride chemical structure
  5. BCC7176 NNC 711 145645-62-1 NNC 711 chemical structure
  6. BCC6930 SKF 89976A hydrochloride SKF89976A hydrochloride is a selective GABA transporter (GAT-1) inhibitor with IC50s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively. SKF 89976A hydrochloride chemical structure
  7. BCC7117 (S)-SNAP 5114 (S)-SNAP5114 is a selective GABA transport inhibitor, with IC50 values of 5 μM and 21 μM for hGAT-3 and rGAT-2, respectively. (S)-SNAP5114 is an anticonvulsant drug. (S)-SNAP 5114 chemical structure
  8. BCC6564 TACA 38090-53-8 TACA chemical structure
  9. BCC5217 Tiagabine hydrochloride Tiagabine hydrochloride is a potent and selective GABA reuptake inhibitor, used as an anticonvulsant agent, with IC50s of 67, 446 and 182 nM for [3H]GABA uptake in Synaptosomes, Neurons and Glia, respectively. Tiagabine hydrochloride chemical structure
  10. BCC6587 cis-ACBD 73550-55-7 cis-ACBD chemical structure
  11. BCC6608 L-CCG-lll 117857-95-1 L-CCG-lll chemical structure

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