Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 45

  1. Cat.No. Product Name Information/Activity
  2. BCC6610 (RS)-MCPG (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons. (RS)-MCPG chemical structure
  3. BCC6611 (S)-MCPG (S)-MCPG is the active isomer of (RS)-MCPG (Cat. (S)-MCPG chemical structure
  4. BCC1777 MPEP Hydrochloride MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM. MPEP Hydrochloride chemical structure
  5. BCC1780 MTEP hydrochloride MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride produces antiparkinsonian-like effects. MTEP hydrochloride chemical structure
  6. BCC6119 NPS 2390 226878-01-9 NPS 2390 chemical structure
  7. BCC6895 PHCCC PHCCC is a Group I metabotropic glutamate receptor antagonist with EC 50 of 6 uM and a positive allosteric modulator of mGluR4. Also as a potent to antagonism for mGluR2 and mGluR8. PHCCC chemical structure
  8. BCC6971 SIB 1757 31993-01-8 SIB 1757 chemical structure
  9. BCC7682 YM 202074 299900-84-8 YM 202074 chemical structure
  10. BCC5956 YM 230888 446257-23-4 YM 230888 chemical structure
  11. BCC7366 YM 298198 hydrochloride 1216398-09-2 YM 298198 hydrochloride chemical structure

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