Alzheimer's Disease Research

Alzheimer's disease (AD), the most common type of dementia, is an irreversible and progressive neurodegenerative disorder causing cognitive and functional impairment. It is characterized by formation of protein aggregates and progressive loss of neurons in the central nervous system (CNS). The symptoms of AD include short-term memory loss, confusion, irritability, aggression and mood swings, progressing to long-term memory deficit, withdrawal from social interactions and subsequently a loss in higher central functioning.

Alzheimer's Disease Research Products Targets

Products for Alzheimer's Disease Research - Page 38

  1. Cat.No. Product Name Information/Activity
  2. BCC4593 (-)-MK 801 (-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects. (-)-MK 801 chemical structure
  3. BCC4014 (+)-MK 801 Maleate Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes. (+)-MK 801 Maleate chemical structure
  4. BCC5859 Norketamine hydrochloride 79499-59-5 Norketamine hydrochloride chemical structure
  5. BCC7895 NPEC-caged-D-AP5 1416943-27-5 NPEC-caged-D-AP5 chemical structure
  6. BCC5644 Pentamidine isethionate Pentamidine isethionate (MP-601205 isethionate) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine isethionate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine isethionate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine isethionate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities. Pentamidine isethionate chemical structure
  7. BCC7308 PMPA (NMDA antagonist) 113919-36-1 PMPA (NMDA antagonist) chemical structure
  8. BCC5918 PPDA 684283-16-7 PPDA chemical structure
  9. BCC7309 PPPA 113190-92-4 PPPA chemical structure
  10. BCC6292 QNZ 46 QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist (IC50 values are 3, 6, 229, and >300, >300 μM for NR2D, NR2C, NR2A, NR2B, and GluR1, respectively). QNZ 46 chemical structure
  11. BCC7129 Remacemide hydrochloride 111686-79-4 Remacemide hydrochloride chemical structure

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