Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 46

  1. Cat.No. Product Name Information/Activity
  2. BCC6555 (-)-Bicuculline methobromide (-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons. (-)-Bicuculline methobromide chemical structure
  3. BCN3763 (-)-Bicuculline methochloride (-)-Bicuculline methochloride (l-Bicuculline methochloride) is a potent GABAA receptor antagonist. (-)-Bicuculline methochloride blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons. (-)-Bicuculline methochloride chemical structure
  4. BCN1238 (+)-Bicuculline (+)-Bicuculline is a light-sensitive competitive antagonist of GABA-A receptor. (+)-Bicuculline chemical structure
  5. BCC3782 Furosemide Furosemide is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema. Furosemide chemical structure
  6. BCC6193 PHP 501 trifluoroacetate 1236105-75-1 PHP 501 trifluoroacetate chemical structure
  7. BCC5705 Picrotoxin Picrotoxin (Cocculin) is a natural noncompetitive antagonist of GABAA receptor, binds to the interface pocket on the GABAR. Picrotoxin (Cocculin) causes overstimulation and induces convulsions. Picrotoxin chemical structure
  8. BCC7266 SCS 3232-36-8 SCS chemical structure
  9. BCC6997 SR 95531 hydrobromide Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor. SR 95531 hydrobromide chemical structure
  10. BCC7510 TB 21007 207306-50-1 TB 21007 chemical structure
  11. BCC7471 U 93631 U93631 is a GABAA receptor ligand of novel chemical structure with IC50 of 100 nM,and has been shown to induce a rapid, time-dependent decay of GABA-induced whole-cell Cl-currents in recombinant GABAA receptors. U 93631 chemical structure

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