Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 50

  1. Cat.No. Product Name Information/Activity
  2. BCC7383 VUF 5681 dihydrobromide 639089-06-8 VUF 5681 dihydrobromide chemical structure
  3. BCC7337 4-Methylhistamine dihydrochloride Selective, high affinity H<sub>4</sub> agonist 4-Methylhistamine dihydrochloride chemical structure
  4. BCC6285 VUF 10460 VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. VUF 10460 chemical structure
  5. BCC7384 VUF 8430 dihydrobromide 100130-32-3 VUF 8430 dihydrobromide chemical structure
  6. BCC7772 A 943931 dihydrochloride Potent and selective H<sub>4</sub> antagonist A 943931 dihydrochloride chemical structure
  7. BCC7732 A 987306 Potent and selective H<sub>4</sub> receptor antagonist A 987306 chemical structure
  8. BCC7362 JNJ 10191584 maleate 869497-75-6 JNJ 10191584 maleate chemical structure
  9. BCC4543 JNJ-7777120 JNJ-7777120 is a selective H4R antagonist with Ki of 4 ±1 nM, exhibits >1000-fold selectivity over the other histamin receptors. JNJ-7777120 chemical structure
  10. BCC6689 L-NIO dihydrochloride L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats. L-NIO dihydrochloride chemical structure
  11. BCC6795 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy. Aminoguanidine hydrochloride chemical structure

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