Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 43

  1. Cat.No. Product Name Information/Activity
  2. BCC5878 ZD 2079 178600-17-4 ZD 2079 chemical structure
  3. BCC6852 ZD 7114 hydrochloride 129689-28-7 ZD 7114 hydrochloride chemical structure
  4. BCC7475 L-748,337 244192-94-7 L-748,337 chemical structure
  5. BCC7094 SR 59230A hydrochloride SR59230A hydrochloride is a potent, selective, and blood-brain barrier penetrating β3-adrenergic receptor antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively. SR 59230A hydrochloride chemical structure
  6. BCC5014 Azilsartan Azilsartan(TAK-536) is a specific and potent angiotensin II type 1 receptor antagonist with IC50 of 2.6 nM. Azilsartan chemical structure
  7. BCC2560 Irbesartan Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM. Irbesartan chemical structure
  8. BCC1080 Losartan Potassium (DuP 753) Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC50 of 20 nM. Losartan Potassium (DuP 753) chemical structure
  9. BCC1819 Olmesartan Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure. Olmesartan chemical structure
  10. BCC2143 Olmesartan medoxomil Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM. Olmesartan medoxomil chemical structure

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