Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 45

  1. Cat.No. Product Name Information/Activity
  2. BCC4860 Sulfisoxazole Sulfisoxazole, an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole chemical structure
  3. BCC5728 BQ-3020 Selective ET<sub>B</sub> agonist BQ-3020 chemical structure
  4. BCC5731 [Ala1,3,11,15]-Endothelin 121204-87-3 [Ala1,3,11,15]-Endothelin chemical structure
  5. BCC5721 Sarafotoxin S6c 121695-87-2 Sarafotoxin S6c chemical structure
  6. BCC5151 BQ-788 sodium salt BQ-788 (sodium salt) is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells. BQ-788 sodium salt chemical structure
  7. BCC7192 IRL-2500 IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo. IRL-2500 chemical structure
  8. BCC5730 IRL-1038 144602-02-8 IRL-1038 chemical structure
  9. BCC4530 Histamine 2HCl Histamine dihydrochloride is an endogenous metabolite. Histamine 2HCl chemical structure
  10. BCC6736 HTMT dimaleate 195867-54-0 HTMT dimaleate chemical structure
  11. BCC7379 2-Pyridylethylamine dihydrochloride 3343-39-3 2-Pyridylethylamine dihydrochloride chemical structure

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