Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 48

  1. Cat.No. Product Name Information/Activity
  2. BCC6768 Imetit dihydrobromide Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM). Imetit dihydrobromide chemical structure
  3. BCC6853 Immepip dihydrobromide 164391-47-3 Immepip dihydrobromide chemical structure
  4. BCC7524 Methimepip dihydrobromide 817636-54-7 Methimepip dihydrobromide chemical structure
  5. BCC5665 (R)-(-)-α-Methylhistamine dihydrobromide (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histamine receptor agonist with a Kd of 50.3 nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, attenuates memory impairment in rats. (R)-(-)-α-Methylhistamine dihydrobromide chemical structure
  6. BCC6700 (S)-(+)-α-Methylhistamine dihydrobromide 75614-93-6 (S)-(+)-α-Methylhistamine dihydrobromide chemical structure
  7. BCC6701 Nα-Methylhistamine dihydrochloride 16503-22-3 Nα-Methylhistamine dihydrochloride chemical structure
  8. BCC7378 Proxyfan oxalate 177708-09-7 Proxyfan oxalate chemical structure
  9. BCC7963 A 331440 dihydrochloride Selective H<sub>3</sub> antagonist A 331440 dihydrochloride chemical structure
  10. BCC1863 Pitolisant hydrochloride Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM). Pitolisant hydrochloride chemical structure
  11. BCC7291 Carcinine ditrifluoroacetate 56897-53-1 Carcinine ditrifluoroacetate chemical structure

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