Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 57

  1. Cat.No. Product Name Information/Activity
  2. BCC5052 LY310762 LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor. LY310762 chemical structure
  3. BCC5047 BRL-54443 BRL 54443 is a potent 5-HT1E/1F receptor agonist (pKi values are 8.7 and 8.9 respectively); displays > 30-fold selectivity over other 5-HT and dopamine receptors. BRL-54443 chemical structure
  4. BCC7559 LY 334370 hydrochloride 199673-74-0 LY 334370 hydrochloride chemical structure
  5. BCC5925 DOI hydrochloride 42203-78-1 DOI hydrochloride chemical structure
  6. BCC8025 NBOH-2C-CN hydrochloride 1539266-32-4 NBOH-2C-CN hydrochloride chemical structure
  7. BCC7285 PNU 22394 hydrochloride 15923-42-9 PNU 22394 hydrochloride chemical structure
  8. BCC7421 TCB-2 912342-28-0 TCB-2 chemical structure
  9. BCC7183 Altanserin hydrochloride 1135280-78-2 Altanserin hydrochloride chemical structure
  10. BCC6194 AT 1015 Long-acting 5-HT<sub>2A</sub> antagonist AT 1015 chemical structure
  11. BCC5037 Clozapine Clozapine (HF 1854) is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM). Clozapine chemical structure

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