Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 42

  1. Cat.No. Product Name Information/Activity
  2. BCC1920 Salmeterol xinafoate Salmeterol xinafoate is a long-acting beta-2 adrenergic receptor (β2AR) agonist, with Ki of 1.5 nM for WT β2AR, and used for asthma treatment. Salmeterol xinafoate chemical structure
  3. BCC6911 Zinterol hydrochloride Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM. Zinterol hydrochloride chemical structure
  4. BCC4029 ICI 118,551 hydrochloride ICI 118,551 (hydrochloride) is a highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. ICI 118,551 hydrochloride chemical structure
  5. BCC6860 BRL 37344, sodium salt BRL 37344 sodium (BRL 37344A) is a specific β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice. BRL 37344, sodium salt chemical structure
  6. BCC6949 CGP 12177 hydrochloride 64208-32-8 CGP 12177 hydrochloride chemical structure
  7. BCC7091 CL 316243 disodium salt 151126-84-0 CL 316243 disodium salt chemical structure
  8. BCC5688 ICI 215,001 hydrochloride 140850-02-8 ICI 215,001 hydrochloride chemical structure
  9. BCC7282 L-755,507 L755507 is a potent, selective agonist of β3-AR with an IC50 of 35 nM. L-755,507 chemical structure
  10. BCC6881 Pindolol Pindolol (LB-46) is a nonselective β-blocker with partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM). Pindolol chemical structure
  11. BCC7833 SR 58611A hydrochloride Amibegron hydrochloride is a selective β3-adrenoceptor agonist, with an EC50 of 3.5 nM for β-adrenoceptor in rat colon; Amibegron hydrochloride has anxiolytic and antidepressant activity. SR 58611A hydrochloride chemical structure

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