Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 32

  1. Cat.No. Product Name Information/Activity
  2. BCC6164 VU 0365114 VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM. VU 0365114 chemical structure
  3. BCC7161 2-Chloro-N6-cyclopentyladenosine Potent, selective A<sub>1</sub> agonist 2-Chloro-N6-cyclopentyladenosine chemical structure
  4. BCC7160 N6-Cyclopentyladenosine N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-Cyclopentyladenosine chemical structure
  5. BCC7716 (±)-5'-Chloro-5'-deoxy-ENBA Highly selective A<sub>1</sub> agonist (±)-5'-Chloro-5'-deoxy-ENBA chemical structure
  6. BCC7215 GR 79236 GR79236 is a highly potent and selective adenosine A1 receptor agonist (Ki = 3.1 nM) that has analgesic and anti-inflammatory actions in humans and animals. GR 79236 chemical structure
  7. BCC7311 2'-MeCCPA 205171-12-6 2'-MeCCPA chemical structure
  8. BCC7374 SDZ WAG 994 130714-47-5 SDZ WAG 994 chemical structure
  9. BCC6664 1,3-Dipropyl-8-phenylxanthine 85872-53-3 1,3-Dipropyl-8-phenylxanthine chemical structure
  10. BCC6649 DPCPX 102146-07-6 DPCPX chemical structure
  11. BCC6124 KW 3902 Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases. KW 3902 chemical structure

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