Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 29

  1. Cat.No. Product Name Information/Activity
  2. BCC7218 AS 19 AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia. AS 19 chemical structure
  3. BCC7517 LP 12 hydrochloride 1185136-22-4 LP 12 hydrochloride chemical structure
  4. BCC7399 LP 44 824958-12-5 LP 44 chemical structure
  5. BCC7990 DR 4485 hydrochloride 402942-53-4 DR 4485 hydrochloride chemical structure
  6. BCC7101 LY 215840 137328-52-0 LY 215840 chemical structure
  7. BCC5937 SB 258719 hydrochloride 1217674-10-6 SB 258719 hydrochloride chemical structure
  8. BCC5056 SB269970 HCl SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors. SB269970 HCl chemical structure
  9. BCC6681 8-Hydroxy-DPAT hydrobromide 76135-31-4 8-Hydroxy-DPAT hydrobromide chemical structure
  10. BCC6266 LP 20 hydrochloride 1386928-34-2 LP 20 hydrochloride chemical structure
  11. BCC7042 McN-A 343 55-45-8 McN-A 343 chemical structure

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