Hypertension Research
Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.
Hypertension Research Products Targets
- Adenosine A2B Receptor (7)
- Adenosine A2A Receptor (11)
- Lipoxygenase (8)
- Leukotriene and Related Receptor (13)
- Bradykinin Receptor (12)
- Others (10)
- Cyclooxygenase (24)
- Apelin Receptor (5)
- 5-HT1F Receptor (2)
- 5-HT1E Receptor (1)
- 5-HT1D Receptor (13)
- 5-HT1B Receptor (20)
- 5-HT1A Receptor (25)
- 5-HT2C Receptor (23)
- 5-HT2B Receptor (12)
- 5-HT2A Receptor (25)
- Natriuretic Peptide Receptor (4)
- Mineralocorticoid Receptor (7)
- Angiotensin-Converting Enzyme (8)
- 5-HT7 Receptor (11)
- 5-HT6 Receptor (14)
- 5-ht5 Receptor (2)
- 5-HT4 Receptor (17)
- Histamine H4 Receptor (12)
- Histamine H3 Receptor (22)
- Histamine H2 Receptor (10)
- Histamine H1 Receptor (17)
- Adenosine A3 Receptor (8)
- Adenosine A1 Receptor (12)
- Calcitonin and Related Receptor (10)
- VIP Receptor (7)
- Vasopressin Receptor (6)
- NO donors and precursors (9)
- nNOS (5)
- iNOS (11)
- eNOS (1)
- Urotensin-II Receptor (8)
- ETB Receptor (6)
- ETA Receptor (5)
- Angiotensin AT2 Receptor (3)
- Angiotensin AT1 Receptor (9)
- M5 Receptor (2)
- M4 Receptor (3)
- M3 Receptor (4)
- Purinergic (P2Y) Receptor (31)
- M2 Receptor (5)
- M1 Receptor (8)
- Neuromedin U (2)
- NKCC (2)
- Adrenergic α2 Receptor (33)
- Adrenergic α1 Receptor (22)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
- Protease-Activated Receptor (23)
- Prostanoid Receptor (24)
- Sphingosine-1-Phosphate Receptor (13)
- Phosphodiesterase (34)
Products for Hypertension Research - Page 28
- Cat.No. Product Name Information/Activity
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BCC7650
BGC 20-761
High affinity 5-HT<sub>6</sub> antagonist
-
BCC6127
MS 245 oxalate
275363-58-1
-
BCC7629
NPS ALX Compound 4a dihydrochloride
NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM.
-
BCC7512
Ro 04-6790
202466-68-0
-
BCC7216
SB 258585 hydrochloride
1216468-02-8
-
BCC1924
SB 271046 hydrochloride
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
-
BCC7750
SGS 518 oxalate
445441-27-0
-
BCC6709
Metergoline
Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors.
-
BCC5663
2-Methyl-5-hydroxytryptamine hydrochloride
2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.
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BCC1114
Mianserin HCl
Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.


