Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 28

  1. Cat.No. Product Name Information/Activity
  2. BCC7650 BGC 20-761 High affinity 5-HT<sub>6</sub> antagonist BGC 20-761 chemical structure
  3. BCC6127 MS 245 oxalate 275363-58-1 MS 245 oxalate chemical structure
  4. BCC7629 NPS ALX Compound 4a dihydrochloride NPS ALX Compound 4a is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM, which also has a great binding affinity with Ki of 0.2 nM. NPS ALX Compound 4a dihydrochloride chemical structure
  5. BCC7512 Ro 04-6790 202466-68-0 Ro 04-6790 chemical structure
  6. BCC7216 SB 258585 hydrochloride 1216468-02-8 SB 258585 hydrochloride chemical structure
  7. BCC1924 SB 271046 hydrochloride SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. SB 271046 hydrochloride chemical structure
  8. BCC7750 SGS 518 oxalate 445441-27-0 SGS 518 oxalate chemical structure
  9. BCC6709 Metergoline Metergoline is a psychoactive drug of the ergoline chemical class which acts as a ligand for various serotonin and dopamine receptors. Metergoline chemical structure
  10. BCC5663 2-Methyl-5-hydroxytryptamine hydrochloride 2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects. 2-Methyl-5-hydroxytryptamine hydrochloride chemical structure
  11. BCC1114 Mianserin HCl Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant. Mianserin HCl chemical structure

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