Arrhythmia Research

An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.

Arrhythmia Research Products Targets

Products for Arrhythmia Research - Page 9

  1. Cat.No. Product Name Information/Activity
  2. BCC7060 DCEBIO DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl- secretion in T84 colonic cells. DCEBIO stimulates Cl- secretion via the activation of hIK1 K+ channels and the activation of an apical membrane Cl- conductance. DCEBIO chemical structure
  3. BCC6904 1-EBIO 10045-45-1 1-EBIO chemical structure
  4. BCC7914 GW 542573X 660846-41-3 GW 542573X chemical structure
  5. BCC7779 NS 1619 NS-1619 is a selective large conductance Ca2+-activated K+-channel activator. NS 1619 chemical structure
  6. BCC1809 NS309 NS309 is a positive modulator of small- and intermediate- conductance Ca2+-activated K+ channels (KCa2 and KCa3.1 channels); increases Ca2+ sensitivity. Displays no activity at BK channels. NS309 chemical structure
  7. BCC7743 SKA 31 SKA-31 is a potent potassium channel activator with EC50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1, KCa2.2, KCa2.1 and KCa2.3, respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure. SKA 31 chemical structure
  8. BCC7141 Apamin Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin chemical structure
  9. BCC6933 Charybdotoxin 95751-30-7 Charybdotoxin chemical structure
  10. BCC6932 Iberiotoxin 129203-60-7 Iberiotoxin chemical structure
  11. BCC7710 Kaliotoxin 145199-73-1 Kaliotoxin chemical structure

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