Arrhythmia Research

An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.

Arrhythmia Research Products Targets

Products for Arrhythmia Research - Page 15

  1. Cat.No. Product Name Information/Activity
  2. BCC1683 KN-93 CaM kinase II inhibitor; also K<sup>+</sup> channel blocker (K<sub>V</sub>),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal <b>CaMK-II</b>, with K<sub>i</sub> of 370 nM. KN-93 chemical structure
  3. BCC7231 Linopirdine dihydrochloride 113168-57-3 Linopirdine dihydrochloride chemical structure
  4. BCC7709 Margatoxin Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research. Margatoxin chemical structure
  5. BCC7927 Psora 4 Potent K<sub>V</sub>1.3 channel blocker Psora 4 chemical structure
  6. BCC6044 RuBi-4AP 851956-02-0 RuBi-4AP chemical structure
  7. BCC5990 ShK-Dap22 220384-25-8 ShK-Dap22 chemical structure
  8. BCC7554 Tetraethylammonium chloride Non-selective K<sup>+</sup> channel blocker Tetraethylammonium chloride chemical structure
  9. BCC7784 UK 78282 hydrochloride 136647-02-4 UK 78282 hydrochloride chemical structure
  10. BCC7232 XE 991 dihydrochloride XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively. XE 991 dihydrochloride chemical structure
  11. BCC4907 Fluticasone propionate Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis. Fluticasone propionate chemical structure

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