Arrhythmia Research

An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.

Arrhythmia Research Products Targets

Products for Arrhythmia Research - Page 13

  1. Cat.No. Product Name Information/Activity
  2. BCC7445 L-364,373 103342-82-1 L-364,373 chemical structure
  3. BCC6213 ML 213 ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. ML 213 chemical structure
  4. BCC7976 ML 277 ML277(CID53347902) is a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator with EC50 of 270 nM. ML 277 chemical structure
  5. BCC7552 NS 1643 NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC50 of 10.5 μM. NS 1643 chemical structure
  6. BCC6190 NS 3623 NS3623 is an activator of human ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates the IKr and Ito currents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS 3623 chemical structure
  7. BCC7872 NS 5806 NS5806, a potent potassium current activator, increases KV4.3/KChIP2 peak current amplitudes with an EC50 of 5.3 μM. NS5806 slows KV4.3 and KV4.2 current dacay in channel complexes containing KChIP2. NS 5806 chemical structure
  8. BCC7499 PD 118057 PD-118057 is a human ether-a-go-go-related gene (hERG) channel activator that does not cause hERG blockade. PD 118057 chemical structure
  9. BCC8026 Agitoxin 2 168147-41-9 Agitoxin 2 chemical structure
  10. BCC6825 AM 92016 hydrochloride AM-92016 hydrochloride is a specific blocker of rectifier potassium current (IK). AM-92016 hydrochloride delays rectifier potassium channel (IK), repolarizes the membrane thereby restricting the duration of the nerve impulse thereby restricting the duration of the nerve impulse. AM 92016 hydrochloride chemical structure
  11. BCC5267 4-Aminopyridine 4-Aminopyridine is a nonselective K+ channel blocker that binds from the cytoplasmic side of the cell membrane. 4-Aminopyridine chemical structure

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