Arrhythmia Research

An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.

Arrhythmia Research Products Targets

Products for Arrhythmia Research - Page 17

  1. Cat.No. Product Name Information/Activity
  2. BCC4378 Carbamazepine Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. Carbamazepine chemical structure
  3. BCC7439 Co 102862 181144-66-1 Co 102862 chemical structure
  4. BCC1578 Flecainide acetate Flecainide acetate (R-818) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. Flecainide acetate chemical structure
  5. BCC6270 Huwentoxin IV 526224-73-7 Huwentoxin IV chemical structure
  6. BCC6358 ICA 121431 ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM). ICA 121431 chemical structure
  7. BCC6327 Jingzhaotoxin III 925463-91-8 Jingzhaotoxin III chemical structure
  8. BCC7618 KC 12291 hydrochloride 181936-98-1 KC 12291 hydrochloride chemical structure
  9. BCC7794 Licarbazepine 29331-92-8 Licarbazepine chemical structure
  10. BCC4677 Mexiletine HCl Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker. Mexiletine HCl chemical structure
  11. BCC5077 Oxcarbazepine Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine chemical structure

Items 161 to 170 of 183 total