ML 213KV7.2 and KV7.4 channel opener CAS# 489402-47-3 |
- BMN-673 8R,9S
Catalog No.:BCC1422
CAS No.:1207456-00-5
- XAV-939
Catalog No.:BCC1120
CAS No.:284028-89-3
- PJ34
Catalog No.:BCC1865
CAS No.:344458-19-1
- ABT-888 (Veliparib)
Catalog No.:BCC1267
CAS No.:912444-00-9
- Veliparib dihydrochloride
Catalog No.:BCC2076
CAS No.:912445-05-7
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 489402-47-3 | SDF | Download SDF |
| PubChem ID | 3111211 | Appearance | Powder |
| Formula | C17H23NO | M.Wt | 257.37 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | DMSO : 30 mg/mL (116.56 mM; Need ultrasonic and warming) | ||
| Chemical Name | N-(2,4,6-trimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide | ||
| SMILES | CC1=CC(=C(C(=C1)C)NC(=O)C2CC3CCC2C3)C | ||
| Standard InChIKey | SIQGKPGBLYKQBB-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19) | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay. |
ML 213 Dilution Calculator
ML 213 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.8855 mL | 19.4273 mL | 38.8546 mL | 77.7091 mL | 97.1364 mL |
| 5 mM | 0.7771 mL | 3.8855 mL | 7.7709 mL | 15.5418 mL | 19.4273 mL |
| 10 mM | 0.3885 mL | 1.9427 mL | 3.8855 mL | 7.7709 mL | 9.7136 mL |
| 50 mM | 0.0777 mL | 0.3885 mL | 0.7771 mL | 1.5542 mL | 1.9427 mL |
| 100 mM | 0.0389 mL | 0.1943 mL | 0.3885 mL | 0.7771 mL | 0.9714 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Guaiol
Catalog No.:BCN6619
CAS No.:489-86-1
- Guaiazulen
Catalog No.:BCC8180
CAS No.:489-84-9
- Globulol
Catalog No.:BCN6901
CAS No.:489-41-8
- Gossypetin
Catalog No.:BCN8075
CAS No.:489-35-0
- Limocitrin
Catalog No.:BCN3346
CAS No.:489-33-8
- Icariin
Catalog No.:BCN6311
CAS No.:489-32-7
- Elesclomol (STA-4783)
Catalog No.:BCC2337
CAS No.:488832-69-5
- N-Acetylstepharine
Catalog No.:BCN7566
CAS No.:4880-87-9
- Furan-3-carboxylic acid
Catalog No.:BCN6397
CAS No.:488-93-7
- D-arabinitol
Catalog No.:BCN5595
CAS No.:488-82-4
- D-Ribitol-5-phosphate
Catalog No.:BCC4838
CAS No.:35320-17-3
- vibo-Quercitol
Catalog No.:BCN5594
CAS No.:488-76-6
- SBC-115076
Catalog No.:BCC6440
CAS No.:489415-96-5
- a-Truxilline
Catalog No.:BCN1947
CAS No.:490-17-5
- Beta-Tocotrienol
Catalog No.:BCN3725
CAS No.:490-23-3
- Robinetin
Catalog No.:BCN5596
CAS No.:490-31-3
- Epicatechin
Catalog No.:BCN5597
CAS No.:490-46-0
- Gaultherin
Catalog No.:BCN2482
CAS No.:490-67-5
- Homoquinolinic acid
Catalog No.:BCC6570
CAS No.:490-75-5
- 2,5-Dihydroxyacetophenone
Catalog No.:BCN3825
CAS No.:490-78-8
- Gentisic acid
Catalog No.:BCN3408
CAS No.:490-79-9
- Valeroidine
Catalog No.:BCN1920
CAS No.:490-96-0
- 4-HQN
Catalog No.:BCC2448
CAS No.:491-36-1
- Quercetin-7-O-beta-D-glucopyranoside
Catalog No.:BCN1261
CAS No.:491-50-9
An Update on the Genetic Polymorphism of HLA-B*27 With 213 Alleles Encompassing 160 Subtypes (and Still Counting).[Pubmed:28247302]
Curr Rheumatol Rep. 2017 Feb;19(2):9.
PURPOSE OF REVIEW: This publication updates an earlier review on the ever increasing knowledge about genetic polymorphism of HLA-B*27 and discusses its clinical relevance. RECENT FINDINGS: As of January 1, 2017, there are 213 known alleles of HLA-B*27 at nucleotide sequence level, while at the translated protein level, there are 160 known subtypes based on one or more amino acid sequence differences. Some of these subtypes exhibit differential association with ankylosing spondylitis, and there may even be some level of hierarchy in this regard. On the other hand, HLA-B*27 has a protective effect against HCV, and this effect is also influenced by some of the subtypes of HLA-B*27. This may have important implications for designing anti-viral vaccines for global population and also for developing individualized treatments and vaccines. Disease association and disease protective roles of HLA-B*27 suggest a common ground, i.e., promoting a more pronounced immune/inflammatory response for effective clearance of some pathogens, but that might, on the other hand, lead to autoimmunity and tissue injury in some circumstances.
Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.[Pubmed:22125664]
ACS Chem Neurosci. 2011 Oct 19;2(10):572-577.
Herein we report the discovery, synthesis and evaluation of a series of N-Aryl-bicyclo[2.2.1]heptane-2-carboxamides as selective KCNQ2 (K(v)7.2) and KCNQ4 (K(v)7.4) channel openers. The best compound, 1 (ML213) has an EC(50) of 230 nM (KCNQ2) and 510 nM (KCNQ4) and is selective for KCNQ2 and KCNQ4 channels versus a large battery of related potassium channels, as well as affording modest brain levels. This represents the first report of unique selectivity profile for KCNQ2 and KCNQ4 over the other channels (KCNQ1/3/5) and as such should prove to be a valuable tool compound for understanding these channels in regulating neuronal activity.
