BCN5942Glycyrrhetinic acid18β-Glycyrrhetinic acid is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
BCN2620Chenodeoxycholic acidChenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
BCC5108CORM-3CORM-3, a water-soluble carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation.
BCC1709LucidinLucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.
BCC5427ISO-1ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC50 of 7 μM.
BCC6132Kisspeptin 10 (rat)Kisspeptin-10, rat is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10, rat is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound.
BCC5316CinchonidineCinchonidine (α-Quinidine) is a cinchona alkaloid found in Cinchona officinalis and Gongronema latifolium. A building block used in asymmetric synthesis in organic chemistry. Weak inhibitor of serotonin transporter (SERT) with Kis of 330, 4.2, 36, 196, 15 μM for dSERT, hSERT, hSERT I172M, hSERT S438T, hSERT Y95F, respectively. Antimalarial activities.
BCC4882ZLN005ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α).
BCC4968EltrombopagEltrombopag(SB-497115) is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.
BCC1549Eltrombopag OlamineEltrombopag Olamine (Eltrombopag diethanolamine salt) is a thrombopoietin-receptor agonist used to treat low blood platelet counts with chronic immune thrombocytopenia.
BCC1328AdaroteneAdarotene is an effective apoptosis inducer, which surprisingly produces DNA damage and exhibites a potent antiproliferative activity on a large panel of human tumor cells.
BCN2916AcetovanilloneApocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM.
BCC4785Guanidine HClIstaroxime hydrochloride is a Na+/K+-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
BCN2208ErgocalciferolIfenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator.
BCC4822PhenylbutazonePhenylbutazone is used as a non-steroidal anti-inflammatory agent for the treatment of chronic pain, including the symptoms of arthritis.
BCC5435OxytocinOxytocin (α-Hypophamine) is a mammalian neurohypophysial hormone; its actions are mediated by specific, high-affinity oxytocin receptors; ligand of oxytocin receptor.
BCN2207Ascorbic acidPROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02. PROTAC EED degrader-1 is a polycomb repressive complex 2 (PRC2) inhibitor (pIC50=8.17) targeting the EED subunit.
BCN1259D-(+)-GlucoseDextrose, a simple sugar (monosaccharide), is an important carbohydrate in biology.
BCC5450L-MimosineL-Mimosine is a non-protein amino acid, and acts as an iron chelator.
BCC3866TerfenadineTerfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
BCC4454MizoribineMizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively.
BCC4917L-ThyroxineL-Thyroxine (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
BCC4062(R)-(-)-Ibuprofen(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
BCC2865L-NAME hydrochlorideL-NAME hydrochloride inhibits NOS with an IC50 of 70 μM. L-NAME is a precursor to NOS inhibitor L-NOARG which has an IC50 value of 1.4 μM.
BCC6663AlrestatinAlrestatin is an inhibitor of aldose reductase, an enzyme involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy.
BCC7832DeoxynivalenolDeoxynivalenol, a mycotoxin of the trichothecenes family, crosses the intestinal mucosa by a paracellular pathway through the tight junctions. The Deoxynivalenol transport is not affected by P-glycoprotein (PgP) or multidrug resistance-associated proteins (MRPs) inhibitors.
BCC8039PMX 205PMX 205 is a potent complement C5a receptor (C5aR; CD88) antagonist.
BCC5322HematoxylinHematoxylin (Hydroxybrazilin) is a compound that forms strongly colored complexes with certain metal ions, notably Fe(III) and Al(III) salts and a kind of stain in histology.
BCC7822TNPTNP is a cell-permeable inhibitor of IP6K1 and IP3K, with IC50 values of 0.55 µM and 10.2 µM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes.
BCN5653KaempferolKaempferol inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK.
BCC5231MedroxyprogesteroneMedroxyprogesterone is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
BCC5279CGP 57380CGP 57380 is a cell-permeable pyrazolo-pyrimidine compound that acts as a selective inhibitor of Mnk1 with IC50 of 2.2 μM, but has no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases.
BCC3831Oxeladin CitrateOxeladin citrate is a cough suppressant, is a highly potent and effective drug used to treat all types of cough of various etiologies.
BCC1679KinetinKinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.
BCC5315AzomycinAzomycin (2-Nitroimidazole) is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria.
BCC4957PrednisonePrednisone (Adasone) is a synthetic corticosteroid agent that is particularly effective as an immunosuppressant compound.
BCC3815Mitotane (Lsodren)Mitotane(2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma.
BCC5383T-5224T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
BCC1569FagomineFagomine is a mild glycosidase inhibitor. The Ki of the iminosugar Fagomine is 4.8 μM, 39 μM, and 70 μM for Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast), respectively.
BCC3813MethyocarbamolMethocarbamol is a central muscle relaxant used to treat skeletal muscle spasms.
BCC6788L-NMMA acetateL-NMMA acetate is a nitric oxide synthase inhibitor of all NOS isoforms including NOS1, NOS2, and NOS3. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 µM, respectively.
BCC3766Diperodon HClDiperodon is a local anaesthetics, by the action of hydrolazes in blood serum is decomposed.
BCC7632MetyraponeMetyrapone is an inhibitor of cytochrome P450-mediated ω/ω-1 hydroxylase activity and CYP11B1.
BCC5185AmifampridineAmifampridine (3,4-Diaminopyridine) is a drug, predominantly in the treatment of a number of rare muscle diseases.
BCC4311PalosuranPalosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.
BCC8054c-di-AMPc-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
BCC1189AcitretinAcitretin(Ro 10-1670) is a second-generation, systemic retinoid that has been used in the treatment of psoriasis.
BCC4557Dexamethasone Sodium PhosphateDexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.
BCC1290(24S)-24,25-Dihydroxyvitamin D3(24S)-24,25-Dihydroxycholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs.
BCC3824NitazoxanideNitazoxanide is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent.
BCC66582,4-Diamino-6-hydroxypyrimidine2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production.
BCC1190AcarboseAcarbose is an inhibitor of alpha glucosidase, an anti-diabetic drug.
BCC4871TorsemideTorsemide is a pyridine-sulfonyl urea type loop diuretic.
BCC8034UreaUrea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
BCN2198ProgesteroneProgesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
BCC1193Pamidronate DisodiumPamidronate disodium, a bisphosphonate drug, can help to strengthen bones.
BCC7412FexaramineFexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.
BCC7659BiocytinBiocytin is a conjugate of D-biotin and L-lysine, where the carboxylate of D-biotin is coupled with the ϵ-amine of L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays.
BCC4202TopiroxostatTopiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
BCC1873Puromycin aminonucleosidePuromycin aminonucleoside (NSC 3056) is the aminonucleoside portion of the antibiotic puromycin, and used in nephrosis animal models. Puromycin aminonucleoside induces apoptosis. Puromycin aminonucleoside is a reversible inhibitor of dipeptidyl peptidase II and cytosol alanyl aminopeptidase.
BCN3841InosineInosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties.
BCC4786HydrochlorothiazideHydrochlorothiazide is a diuretic drug of the thiazide class.
BCC3752ChlorothiazideChlorothiazide is a diuretic and antihypertensive. (IC50=3.8 mM)
BCC5210ProcaineProcaine is a DNA-demethylating agent. Procaine acts through multiple targets and has a slow onset and a short duration of action.
BCC4365Megestrol AcetateMegestrol Acetate is a synthetic progesteronal agent with an IC50 of 260 μM for the inhibition of HegG2.
BCC7359AC 55649AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
BCC7205N-Formyl-Met-Leu-PheN-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR).
BCC2545SulfasalazineSulfasalazine is a drug for the treatment of rheumatoid arthritis and ulcerative colitis. Sulfasalazine is reported to suppress NF-κB activity.
BCC4888(6-)ε-Aminocaproic acid6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.
BCC3812MethimazoleMethimazole is an antithyroid medicine used for the treatment of the hyperthyroidism in humans and animals.
BCC1835PamabromPamabron is a common over-the-counter diuretic used for relief of menstrual-associated symptoms.
BCC3804Lithium CitrateCitric acid trilithium salt tetrahydrate is a pharmaceutical and construction material, used in HPLC gradient elution for quantitative amino acid analysis.
BCC4283L-Thyroxine sodium salt pentahydrateL-Thyroxine sodium salt pentahydrate(Levothyroxine) is an iodine containing hormone produced from thyroglobulin in the thyroid follicular cells; reduces total cholesterol level, low-density lipoprotein cholesterol as well as waist to hip ratio in subclinical hypothyroidism pateints.
BCC3996VorapaxarVorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner.
BCC1899RiociguatRiociguat is an oral stimulator of soluble guanylate cyclase (sGC) used in the treatment of pulmonary hypertension.
BCC5447OxiracetamOxiracetam is a cyclic derivative of γ-aminobutyric acid (GABA) which has been commonly used as nootropic drug to treat cognitive impairments.
BCC5472BromethalinBromethalin is a new rodenticide for the control of commensal rodents; doses in excess of the LD50 (2 mg/kg in rats) will cause death.
