Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 74

  1. Cat.No. Product Name Information/Activity
  2. BCC7528 MMPIP hydrochloride 479077-02-6 MMPIP hydrochloride chemical structure
  3. BCC6818 MPPG 169209-65-8 MPPG chemical structure
  4. BCC7033 UBP1112 339526-74-8 UBP1112 chemical structure
  5. BCC6150 TC-N 22A 1314140-00-5 TC-N 22A chemical structure
  6. BCC7901 TCN 238 TCN238 is a positive allosteric mGlu4 receptor modulator with an EC50 of 1 μM. TCN 238 chemical structure
  7. BCC4596 VU 0361737 VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors. VU 0361737 chemical structure
  8. BCC1239 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. VU 0364439 chemical structure
  9. BCC4597 VU 0364770 VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively. VU 0364770 chemical structure
  10. BCC2412 Pifithrin-μ Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity. Pifithrin-μ chemical structure
  11. BCC2338 VER 155008 VER-155008 is an inhibitor of Hsp70, with IC50s of 0.5 μM, 2.6 μM, and 2.6 μM for Hsp70, Hsc70 and Grp7, respectively, and with a Kd of 0.3 μM for Hsp70. VER 155008 chemical structure

Items 731 to 740 of 752 total