Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3351 | Kushenol C |
| Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). Kushenol C shows antimicrobial activity against Staphylococcus aureus and Streptococcus mutans. Kushenol C may be potent preventive and therapeutic candidates for Alzheimer's disease, it (IC(50) 5.45 microM) can inhibit beta-site APP cleaving enzyme 1 (BACE1) activities. | |
| BCN3353 | 3-O-Feruloylquinic acid |
| 1. 3-O-Feruloylquinic acid is a protease inhibitor. 2. 3-O-Feruloylquinic acid exerts moderate inhibitory effect against AIV (H5N1) in vitro. | |
| BCN3360 | Alisol F |
| 1. Alisol F suppresses iNOS induction. 2. Alisol F and 25-Anhydroalisol F show anti-inflammatory activities and liver protection through the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivo. 3. Alisol F exhibits inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells. 4. Alisol F exhibits inhibitory activity in vitro on hepatitis B virus (HBV) surface antigen (HBsAg) secretion of the Hep G2.2.15 cell line with the IC (50) value of 0.6 microM, and on HBV e antigen (HBeAg) secretion with the IC (50) value of 8.5 microM. | |
| BCN3361 | 25-Anhydroalisol F |
| 1. 25-Anhydroalisol F shows anti-inflammatory activities and liver protection through the inhibition of MAPK, STAT3, and NF-κB activation in vitro and in vivo. 3. 25-Anhydroalisol F exhibits inhibitory effects on lipopolysaccharide-induced NO production in RAW 264.7 macrophage cells. | |
| BCN3364 | Alisol B |
| 1. Alisol B can suppress C3a induced epithelial-mesenchymal transition . 2. Alisol B may be a potential novel therapeutic molecule for bone disorders through targeting the differentiation of osteoclasts as well as their functions. 3. Alisol B also inhibited RANKL-induced expression of NFATc1 and c-Fos, which are key transcription factors for osteoclastogenesis. 4. The molecular target of Alisol B is the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase, it provides detailed insights into the cytotoxic mechanism of a novel antitumor compound. | |
