Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3564 | Kawain |
| Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose. | |
| BCN3565 | Yangonin |
| Yangonin is a novel CB₁ receptor ligand, it exhibits affinity for the human recombinant CB₁ receptor, it is also an effective inhibitor of EV-A71 infection in the low-micromolar. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation.Yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway. | |
| BCN3567 | Hispidin |
| 1. Hispidin exhibits anti-inflammatory activity through suppressing ROS mediated NF-κB pathway in mouse macrophage cells. 2. Hispidin has anti-cancer activity by inducing both intrinsic and extrinsic apoptotic pathways mediated by ROS in colon cancer cells. 3. Hispidin can inhibit Acrylamide-induced oxidative stress and protect C2C12 myotubes against palmitate-induced oxidative stress by suppressing cleavage of caspase-3, expression of Bax, and NF-κB translocation. 4. Hispidin protects against apoptosis in H9c2 cardiomyoblast cells exposed to hydrogen peroxide through reducing intracellular ROS production, regulating apoptosis-related proteins, and the activation of the Akt/GSK-3β and ERK1/2 signaling pathways. | |
| BCN3571 | Broussoflavonol F |
| 1. Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. 2. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. 3. Broussoflavonol F shows radical scavenging against 2,2-diphenyl-1-picrylhydrazyl (DPPH), the IC50 value of 708.54 uM. 4. Broussoflavonol F exhibits moderate cytotoxic activities against five human cancer cells with the IC50 value of 0.41-7.2 ug/mL. | |
| BCN3572 | 3',5'-Diprenylgenistein |
| 1. 3',5'-Diprenylgenistein inhibits protein tyrosine phosphatase 1B (PTP1B) activities, it can reduce muscle cell viability. 2. 3',5'-Diprenylgenistein exhibits significant glucose-uptake activity in basal and insulin-stimulated L6 myotubes. | |
