Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3125 | Tanshindiol C |
| 1. Tanshindiol C exhibits most powerful cytotoxic effects against tested tumor cells. 2. Tanshinones plays significant roles in the inhibition and induction of several CYP450 isozymes. | |
| BCN3128 | Isochamaejasmine |
| Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the activity of Bcl-2 family proteins, providing evidence for further studying the underlying anti-cancer mechanism of S. chamaejasme L. Isochamaejasmine shows antiplasmodial activity, with an IC(50) of 7.3+/-3.8 microM, but the selectivity was rather limited. | |
| BCN3145 | Danshenol A |
| 1. Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. 2. Danshenol A has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines. | |
| BCN3164 | Sugiol |
| 1. Sugiol has antioxidant efficacy. 2. Sugiol has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals. 3. Sugiol's efficacy in inhibiting the inflammatory cytokines of IL-1beta and TNF-alpha could be attributed to a reduction of the ROS that leads to a decrease in the phosphorylation of MAPKs. | |
| BCN3173 | 3-Epiursolic acid |
| 1. 3-Epiursolic acid shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 uM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the development of novel anticancer agents. 2. 3-Epiursolic acid may have antiinflammatory activity. | |
