Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 53

  1. Cat.No. Product Name Information/Activity
  2. BCC6624 NBQX NBQX is a highly selective and competitive AMPA receptor antagonist. NBQX chemical structure
  3. BCC6907 NBQX disodium salt 479347-86-9 NBQX disodium salt chemical structure
  4. BCC7478 Philanthotoxin 74 Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. Philanthotoxin 74 chemical structure
  5. BCC6866 SYM 2206 SYM 2206 is a novel, potent, non-competitive AMPA receptor antagonist. SYM 2206 chemical structure
  6. BCC6378 Talampanel(LY300164) Talampanel is a potent and selective AMPA-receptor antagonist, is a potential new antiepileptic drug (AED). Talampanel(LY300164) chemical structure
  7. BCC7171 UBP 282 544697-47-4 UBP 282 chemical structure
  8. BCC7455 YM 90K hydrochloride 154164-30-4 YM 90K hydrochloride chemical structure
  9. BCC7339 ZK 200775 Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonist with little activity against NMDA; have Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. ZK 200775 chemical structure
  10. BCC6151 CMPDA CMPDA is a positive allosteric modulator of AMPA receptors with EC50s of 45.4 ± 4.2 nM/63.4 ± 5.6 nM for GluA2i/GluA2o receptor. CMPDA chemical structure
  11. BCC7532 CX 546 CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent. CX 546 chemical structure

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