Epilepsy Research

Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.

Epilepsy Research Products Targets

Products for Epilepsy Research - Page 55

  1. Cat.No. Product Name Information/Activity
  2. BCC6270 Huwentoxin IV 526224-73-7 Huwentoxin IV chemical structure
  3. BCC6358 ICA 121431 ICA-121431 is a nanomolar potent and broad-spectrum voltage-gated sodium channel (Nav) blocker, shows equipotent selectivity for human Nav1.1 and Nav1.3 subtypes with IC50 values of 13 nM and 23 nM, respectively. ICA-121431 shows less potent inhibition of Nav1.2 (IC50=240 nM) and 1,000 fold selectivity against Nav1.4, Nav1.6, and the TTX-resistant human Nav1.5 and Nav1.8 channels (IC50s >10 µM). ICA 121431 chemical structure
  4. BCC6327 Jingzhaotoxin III 925463-91-8 Jingzhaotoxin III chemical structure
  5. BCC7618 KC 12291 hydrochloride 181936-98-1 KC 12291 hydrochloride chemical structure
  6. BCC7794 Licarbazepine 29331-92-8 Licarbazepine chemical structure
  7. BCC4677 Mexiletine HCl Mexiletine hydrochloride (KOE-1173 hydrochloride), a Class IB antianhythmic, is a non-selective voltage-gated sodium channel blocker. Mexiletine HCl chemical structure
  8. BCC5077 Oxcarbazepine Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine chemical structure
  9. BCC6328 Phrixotoxin 3 880886-00-0 Phrixotoxin 3 chemical structure
  10. BCC6103 ProTx II ProTx II is a selective blocker of Nav1.7 sodium channels with an IC50 of 0.3 nM, and is at least 100-fold selective for Nav1.7 over other sodium channel subtypes. ProTx-II inhibits sodium channels by decreasing channel conductance and shifting activation to more positive potentials and blocks action potential propagation in nociceptors. ProTx II chemical structure
  11. BCC6906 QX 222 5369-00-6 QX 222 chemical structure

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