Gap Channel
Gap channels (gap junctions) are specialized cell-cell contacts that provide direct intracellular communication. They allow passive diffusion of molecules up to 1 kDa, including nutrients, metabolites (glucose), ions (K+, Ca2+) and second messengers (IP3, cAMP).
Products for Gap Channel
- Cat.No. Product Name Information/Activity
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BCC3931
Trovafloxacin mesylate
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC50 of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.
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BCC1245
10Panx
Panx-1 mimetic inhibitory peptide; blocks pannexin-1 gap junctions
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BCC1246
Scrambled 10Panx
Scrambled version of <sup>10</sup>Panx, Panx-1 mimetic inhibitory peptide
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BCC3745
Carbenoxolone disodium
7421-40-1
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BCC1032
Gap 26
Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
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BCC1033
Gap 27
Gap 27, connexin43 mimetic peptide, is a gap junction inhibitor.
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BCC5599
Gap19
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial.
