Epilepsy Research

Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.

Epilepsy Research Products Targets

Products for Epilepsy Research - Page 54

  1. Cat.No. Product Name Information/Activity
  2. BCC6294 APETx2 713544-47-9 APETx2 chemical structure
  3. BCC1451 Capsazepine Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM. Capsazepine chemical structure
  4. BCC7673 Phenamil 1161-94-0 Phenamil chemical structure
  5. BCC7515 Veratridine Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Veratridine chemical structure
  6. BCC5075 A-803467 A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. A-803467 chemical structure
  7. BCC7898 A 887826 A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo. A 887826 chemical structure
  8. BCC5067 Ambroxol HCl Na<sup>+</sup> channel blocker,AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 μM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3. Ambroxol HCl chemical structure
  9. BCC4378 Carbamazepine Carbamazepine, a sodium channel blocker, is an anticonvulsant drug. Carbamazepine chemical structure
  10. BCC7439 Co 102862 181144-66-1 Co 102862 chemical structure
  11. BCC1578 Flecainide acetate Flecainide acetate (R-818) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. Flecainide acetate chemical structure

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