Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 16

  1. Cat.No. Product Name Information/Activity
  2. BCC6227 TC-E 5005 959705-64-7 TC-E 5005 chemical structure
  3. BCN1258 Theophylline Theophylline is a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. Theophylline chemical structure
  4. BCC7333 Trequinsin hydrochloride 78416-81-6 Trequinsin hydrochloride chemical structure
  5. BCN2609 Vinpocetine Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders. Vinpocetine chemical structure
  6. BCC7190 YM 976 191219-80-4 YM 976 chemical structure
  7. BCC6859 Zaprinast Zaprinast (M&B 22948) is an inhibitor of cGMP-selective Phosphodiesterases(PDEs). Zaprinast is a G protein-coupled receptor (GPR) 35 agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects. Zaprinast chemical structure
  8. BCC2069 Zardaverine Zardaverine is a newly developed dual-selective PDE3/4 inhibitor with IC50 values of 0.5 uM and 0.8 uM respectively. Zardaverine chemical structure
  9. BCC4270 Deltarasin hydrochloride 1440898-82-7 Deltarasin hydrochloride chemical structure
  10. BCC7068 BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist BMY 45778 chemical structure
  11. BCC7315 (±)-Cloprostenol sodium salt Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent, and is a PGF2α receptor agonist. (±)-Cloprostenol sodium salt chemical structure

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