Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 14

  1. Cat.No. Product Name Information/Activity
  2. BCC6843 Cilostamide Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Cilostamide chemical structure
  3. BCC2291 Cilostazol Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. Cilostazol chemical structure
  4. BCC7155 Enoximone 77671-31-9 Enoximone chemical structure
  5. BCC6648 Etazolate hydrochloride 35838-58-5 Etazolate hydrochloride chemical structure
  6. BCC7502 IBMX IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. IBMX chemical structure
  7. BCC7188 ICI 63197 27277-00-5 ICI 63197 chemical structure
  8. BCC7066 MDL 12330A hydrochloride Cyclic nucleotide PDE inhibitor; also adenylyl cyclase inhibitor MDL 12330A hydrochloride chemical structure
  9. BCC7549 Mesopram 189940-24-7 Mesopram chemical structure
  10. BCC4374 Milrinone Milrinone is a PDE3 inhibitor, and also an inotrope and vasodilator. Milrinone chemical structure
  11. BCC6692 MMPX 78033-08-6 MMPX chemical structure

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