Hypertension Research

Hypertension is defined as a chronic elevation in blood pressure with a systolic pressure over 140 mmHg and a diastolic pressure over 90 mmHg.The majority of hypertension is primary - that is, an increase in blood pressure with no underlying cause - yet pathologies that affect the kidney or endocrine system may also trigger hypertension. This is known as secondary hypertension. The exact mechanism of primary hypertension is yet to be elucidated, though dysfunctions in mechanisms that regulate vascular tone, both directly and indirectly, have been identified as having a major influence on hypertension.

Hypertension Research Products Targets

Products for Hypertension Research - Page 19

  1. Cat.No. Product Name Information/Activity
  2. BCC5941 SC 51322 146032-79-3 SC 51322 chemical structure
  3. BCC3952 AC 264613 PAR<sub>2</sub> receptor agonist AC 264613 chemical structure
  4. BCC3951 AC 55541 AC-55541 is a highly selective protease-activated receptor 2 (PAR2) agonist (pEC50=6.7), displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. AC-55541 has pEC50 values of 5.9 and 6.6 in PI hydrolysis assays and Ca2+ mobilization assays and exhibits pronociceptive activity in vivo. AC 55541 chemical structure
  5. BCC3949 AY-NH2 PAR-4 Agonist Peptide, amide (PAR-4-AP; AY-NH2) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist. AY-NH2 chemical structure
  6. BCC3958 2-Furoyl-LIGRLO-amide 2-Furoyl-LIGRLO-amide is a potent and selective proteinase-activated receptor 2 (PAR2) agonist with a pD2 value of 7.0.. 2-Furoyl-LIGRLO-amide chemical structure
  7. BCC3955 LRGILS-NH2 245329-01-5 LRGILS-NH2 chemical structure
  8. BCC3954 RLLFT-NH2 447408-68-6 RLLFT-NH2 chemical structure
  9. BCC3959 SLIGKV-NH2 Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide. SLIGKV-NH2 chemical structure
  10. BCC3947 SLIGRL-NH2 Protease-Activated Receptor-2 Activating Peptide is an agonist of Protease-Activated Receptor-2 (PAR-2). SLIGRL-NH2 chemical structure
  11. BCC3948 TFLLR-NH2 TFLLR-NH2 is a selective PAR1 agonist with an EC50 of 1.9 μM. TFLLR-NH2 chemical structure

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