IsosaxalinCAS# 55481-86-2 |
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Chemical structure
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| Cas No. | 55481-86-2 | SDF | Download SDF |
| PubChem ID | 91885198 | Appearance | Powder |
| Formula | C16H15ClO5 | M.Wt | 322.7 |
| Type of Compound | Coumarins | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 9-[(2R)-3-chloro-2-hydroxy-3-methylbutoxy]furo[3,2-g]chromen-7-one | ||
| SMILES | CC(C)(C(COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2)O)Cl | ||
| Standard InChIKey | VNNTVHKCIBWHDR-LLVKDONJSA-N | ||
| Standard InChI | InChI=1S/C16H15ClO5/c1-16(2,17)11(18)8-21-15-13-10(5-6-20-13)7-9-3-4-12(19)22-14(9)15/h3-7,11,18H,8H2,1-2H3/t11-/m1/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Angelica polymorpha Maxim.
| Description | 1. Isosaxalin, heraclenin and heraclenol 3'-Me ether have melanin biosynthesis inhibitory activities . |
Isosaxalin Dilution Calculator
Isosaxalin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.0989 mL | 15.4943 mL | 30.9885 mL | 61.9771 mL | 77.4713 mL |
| 5 mM | 0.6198 mL | 3.0989 mL | 6.1977 mL | 12.3954 mL | 15.4943 mL |
| 10 mM | 0.3099 mL | 1.5494 mL | 3.0989 mL | 6.1977 mL | 7.7471 mL |
| 50 mM | 0.062 mL | 0.3099 mL | 0.6198 mL | 1.2395 mL | 1.5494 mL |
| 100 mM | 0.031 mL | 0.1549 mL | 0.3099 mL | 0.6198 mL | 0.7747 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Melanin biosynthesis inhibitory activities of coumarins isolated from Angelica polymorpha MAXIM
Korean Journal of Microbiology & Biotechnology, 2003 , 47 (12) :3829-36.
During the screening for inhibitors of melanin biosynthesis from plant extract, Angelica polymorpha MAXIM which showed a high lecel of inhibition was selected. The inhibiting substances were purified form methanol extract of Angelica Polymorpha MAXIM followed by silica gel column chromatography and HPLC. The inhibitors were identified as heraclenin, Isosaxalin and heraclenol 3'-Me ether , by spectroscopic methods of ESI-MS, ©öH-NMR,©ö©øC-NMR, DEPT, HMQC and HMBC. These compounds did not have mushroom tyrosinase inhibitory activity, but showed a highly potent melanin biosynthesis inhibition zone in the plate culture of Streptomyces bikiniensis, a bacterium used as an indicator organism in this work. These compounds did not show any growth inhibition against S. bikiniensis at the same concentration of melanin biosynthesis test
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