Parkinson's Disease Research

Parkinson's disease (PD) is a degenerative disease of the central nervous system that often impairs motor skills, speech, and other functions. Symptoms of the disease include resting tremor, bradykinesia and rigidity. The primary symptoms are the result of decreased stimulation of the motor cortex by the basal ganglia, normally caused by the insufficient formation and action of dopamine, which is produced in the dopaminergic neurons of the brain. Symptoms of the disease appear once 50-80% of dopamine neurons have died. Parkinson's disease is both chronic and progressive.

Parkinson's Disease Research Products Targets

Products for Parkinson's Disease Research - Page 21

  1. Cat.No. Product Name Information/Activity
  2. BCC1902 RJR-2403 oxalate Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). RJR-2403 oxalate chemical structure
  3. BCC7975 SIB 1508Y maleate 192231-16-6 SIB 1508Y maleate chemical structure
  4. BCC7469 TC 2559 difumarate 212332-35-9 TC 2559 difumarate chemical structure
  5. BCN2170 Varenicline tartrate Varenicline Tartrate(CP 526555;Champix) is a nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does. Varenicline tartrate chemical structure
  6. BCC7341 Dihydro-β-erythroidine hydrobromide Dihydro-β-erythroidine (DHβE) hydrobromide is a potent, orally active and competitive antagonist of neuronal nicotinic acetyicholine receptors (nAChRs). Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. Antidepressant-like activities. Dihydro-β-erythroidine hydrobromide chemical structure
  7. BCC7301 DMAB-anabaseine dihydrochloride 154149-38-9 DMAB-anabaseine dihydrochloride chemical structure
  8. BCC7651 Desformylflustrabromine hydrochloride Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48. Desformylflustrabromine hydrochloride chemical structure
  9. BCC7869 LY 2087101 913186-74-0 LY 2087101 chemical structure
  10. BCC7468 Sazetidine A dihydrochloride 1197329-42-2 Sazetidine A dihydrochloride chemical structure
  11. BCC7920 A 582941 848591-90-2 A 582941 chemical structure

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