Epilepsy Research

Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.

Epilepsy Research Products Targets

Products for Epilepsy Research - Page 37

  1. Cat.No. Product Name Information/Activity
  2. BCC7332 JNJ 16259685 JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. JNJ 16259685 chemical structure
  3. BCC6983 LY 367385 LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects. LY 367385 chemical structure
  4. BCC7347 LY 456236 hydrochloride 338736-46-2 LY 456236 hydrochloride chemical structure
  5. BCC7281 3-MATIDA 518357-51-2 3-MATIDA chemical structure
  6. BCC7756 (RS)-MCPG disodium salt 1303994-09-3 (RS)-MCPG disodium salt chemical structure
  7. BCC6610 (RS)-MCPG (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons. (RS)-MCPG chemical structure
  8. BCC6611 (S)-MCPG (S)-MCPG is the active isomer of (RS)-MCPG (Cat. (S)-MCPG chemical structure
  9. BCC1777 MPEP Hydrochloride MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype with IC50 of 36 nM. MPEP Hydrochloride chemical structure
  10. BCC1780 MTEP hydrochloride MTEP hydrochloride is a potent, selective and non-competitive mGlu5 antagonist with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride produces antiparkinsonian-like effects. MTEP hydrochloride chemical structure
  11. BCC6119 NPS 2390 226878-01-9 NPS 2390 chemical structure

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