Epilepsy Research
Epilepsy is a group of neurological conditions consisting of recurrent, usually unprovoked epileptic seizures. Epileptic seizures have recently been defined as "a transient occurrence of signs and/or symptoms due to abnormal, excessive or synchronous neuronal activity in the brain". Epilepsy is one of the most common disorders of the brain, with one in 10 people suffering at least one seizure in their lifetime. There are over 40 different types of epilepsy, each of which presents with its own unique combination of seizure type, typical age of onset, EEG findings, treatment, and prognosis.
Epilepsy Research Products Targets
- NHE (3)
- Monocarboxylate Transporter (3)
- VEGFR (16)
- FGFR (5)
- Voltage-gated Sodium (NaV) Channel (30)
- Voltage-gated Potassium (KV) Channel (38)
- Voltage-gated Calcium Channel (CaV) (38)
- Others (13)
- Epithelial Sodium Channel (3)
- STIM-Orai Channel (4)
- Ryanodine Receptor (6)
- Glutamate (Metabotropic) Group III Receptor (26)
- Glutamate (Metabotropic) Group II Receptor (33)
- Glutamate (Metabotropic) Group I Receptor (54)
- AMPA Receptor (45)
- GABAA-ρ Receptor (8)
- GABAA Receptor (66)
- NMDA Receptor (87)
- Kainate Receptor (22)
- IP3 Receptor (2)
- Gap Channel (7)
- Trk Receptor (13)
- Acid-Sensing Ion Channel (3)
- Calcium-Activated Potassium (KCa) Channel (19)
- Inward Rectifier Potassium (Kir) Channel (21)
- Sodium and Potassium ATPase (3)
- KCC2 (1)
- H+-ATPase (3)
- H+,K+-ATPase (4)
- Chloride Channel (17)
- NCX (5)
- Ca2+-ATPase (7)
- NKCC (2)
- Cytokine (15)
Products for Epilepsy Research - Page 30
- Cat.No. Product Name Information/Activity
-
BCC6999
D-CPP-ene
117414-74-1
-
BCC6592
5,7-Dichlorokynurenic acid
131123-76-7
-
BCC7758
5,7-Dichlorokynurenic acid sodium salt
1184986-70-6
-
BCC6619
(±)-1-(1,2-Diphenylethyl)piperidine maleate
207461-99-2
-
BCC6205
DQP 1105
380560-89-4
-
BCC7280
Eliprodil
Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).
-
BCC4904
Felbamate
Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
-
BCC7340
Gavestinel
153436-38-5
-
BCC6589
(S)-(-)-HA-966
111821-58-0
-
BCC5946
HU 211
Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative and lacks cannabimimetic effects. Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death. Dexanabinol is widely used in head injury or stroke treatment and has been shown to be safe in animals and humans.


