Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 38

  1. Cat.No. Product Name Information/Activity
  2. BCC7280 Eliprodil Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM). Eliprodil chemical structure
  3. BCC4904 Felbamate Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). Felbamate chemical structure
  4. BCC4456 Flupirtine maleate Flupirtine Maleate(D 9998) is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties. Flupirtine maleate chemical structure
  5. BCC7340 Gavestinel 153436-38-5 Gavestinel chemical structure
  6. BCC6589 (S)-(-)-HA-966 111821-58-0 (S)-(-)-HA-966 chemical structure
  7. BCC5946 HU 211 Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative and lacks cannabimimetic effects. Dexanabinol exhibits not only the antioxidant and neuroprotective activities in brain but also anti-inflammatory activity by inhibiting NF-κB and decreasing cytokines such as TNFα and interleukin-6, which could ensure the integrity of BBB and reduce cell apoptosis and death. Dexanabinol is widely used in head injury or stroke treatment and has been shown to be safe in animals and humans. HU 211 chemical structure
  8. BCC6594 N-(4-Hydroxyphenylacetyl)spermine 130210-32-1 N-(4-Hydroxyphenylacetyl)spermine chemical structure
  9. BCC7508 threo Ifenprodil hemitartrate 1312991-83-5 threo Ifenprodil hemitartrate chemical structure
  10. BCC5982 Ketamine hydrochloride 1867-66-9 Ketamine hydrochloride chemical structure
  11. BCC7930 (S)-(+)-Ketamine hydrochloride 33643-47-9 (S)-(+)-Ketamine hydrochloride chemical structure

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