Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 33

  1. Cat.No. Product Name Information/Activity
  2. BCC2177 SNS-314 Mesylate SNS-314 is a potent and selective aurora kinase inhibitor with IC50s of 9, 31, and 6 nM for aurora A, B and C, respectively. SNS-314 Mesylate chemical structure
  3. BCC2418 TC-A 2317 hydrochloride Potent, selective Aurora kinase A inhibitor TC-A 2317 hydrochloride chemical structure
  4. BCC2182 Aurora A Inhibitor I Potent and selective Aurora kinase A inhibitor,Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I chemical structure
  5. BCC2167 VX-680 (MK-0457,Tozasertib) Tozasertib (VX 680; MK-0457) is an inhibitor of Aurora A/B/C kinases with Kis of 0.6, 18, 4.6 nM, respectively. VX-680 (MK-0457,Tozasertib) chemical structure
  6. BCC2169 ZM 447439 ZM-447439 is an aurora kinase inhibitor with IC50s of 110 and 130 nM for aurora A and B, respectively. ZM 447439 chemical structure
  7. BCN2483 Ginkgolic acid C15:0 Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC50s of ∼8.5 μM and ∼5 μM, respectively. Ginkgolic acid C15:0 chemical structure
  8. BCC4100 PCI 29732 PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay. PCI 29732 chemical structure
  9. BCC6268 PF 06465469 PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2 nM. PF 06465469 chemical structure
  10. BCC7051 (-)-Terreic acid Selective inhibitor of BTK (-)-Terreic acid chemical structure
  11. BCC6203 A 484954 A-484954 is a highly selective eukaryotic elongationfactor-2 (eEF2) inhibitor, with an IC50 of 280 nM. A 484954 chemical structure

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