Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 26

  1. Cat.No. Product Name Information/Activity
  2. BCC3737 Bexarotene Bexarotene (LGD1069) is a selective retinoid X receptors (RXR) agonist for the treatment of cutaneous T-cell lymphoma. Bexarotene chemical structure
  3. BCC7637 CD 3254 CD3254 a potent and selective retinoid-X-receptor (RXR) agonist. CD 3254 chemical structure
  4. BCC6110 Fluorobexarotene Fluorobexarotene (compound 20) is a potent retinoid-X-receptor (RXR) agonist, with a Ki value of 12 nM and an EC50 value of 43 nM for RXRα receptor. Fluorobexarotene possesses an apparent RXR binding affinity that is 75% greater than Bexarotene. Fluorobexarotene chemical structure
  5. BCC7681 SR 11237 146670-40-8 SR 11237 chemical structure
  6. BCC6082 HX 531 188844-34-0 HX 531 chemical structure
  7. BCC8005 PA 452 PA452, retinoic X receptor (RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development. PA 452 chemical structure
  8. BCC7638 UVI 3003 UVI 3003 is a highly selective antagonist of retinoid X receptor (RXR), and inhibits xenopus and human RXRα in Cos7 cells, with IC50s of 0.22 and 0.24 μM, respectively. UVI 3003 chemical structure
  9. BCC7696 LG 101506 331248-11-4 LG 101506 chemical structure
  10. BCC6083 HX 630 188844-52-2 HX 630 chemical structure
  11. BCC7786 LG 100754 LG100754 (UVI 2112) is a RXR dimers modulater. LG100754 acts as a RXR:RXR homodimer antagonist, but functions as a agonist towards RXR:PPARα and RXR:PPARγ heterodimers. LG100754 is an insulin sensitizer that functions through RXR. LG 100754 chemical structure

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