Intracellular Signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.

Intracellular Signaling Products Targets

Products for Intracellular Signaling - Page 37

  1. Cat.No. Product Name Information/Activity
  2. BCC5837 [Ala92]-p16 (84-103) 189064-08-2 [Ala92]-p16 (84-103) chemical structure
  3. BCC5654 Purvalanol A Purvalanol A is a potent CDK inhibitor, which inhibits cdc2-cyclin B, cdk2-cyclin A, cdk2-cyclin E, cdk4-cyclin D1, and cdk5-p35 with IC50s of 4, 70, 35, 850, 75 nM, resepctively. Purvalanol A chemical structure
  4. BCC3887 Purvalanol B Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Purvalanol B chemical structure
  5. BCC4007 Ro 3306 Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Ro 3306 chemical structure
  6. BCC1105 Roscovitine (Seliciclib,CYC202) Seliciclib (Roscovitine) is an orally bioavailable and selective CDKs inhibitor with IC50s of 0.2 μM, 0.65 μM, and 0.7 μM for CDK5, Cdc2, and CDK2, respectively. Roscovitine (Seliciclib,CYC202) chemical structure
  7. BCC7432 Ryuvidine 265312-55-8 Ryuvidine chemical structure
  8. BCC1152 SNS-032 (BMS-387032) SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK2, CDK7, and CDK9 with IC50s of 38 nM, 62 nM and 4 nM, respectively. SNS-032 has antitumor effect. SNS-032 (BMS-387032) chemical structure
  9. BCC2398 SU 9516 SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also shows inhibitory effects on CDK1 and CDK4, with IC50s of 40, 200 nM, respectively. SU 9516 chemical structure
  10. BCC2400 DAPK Substrate Peptide Death associated protein kinase substrate (synthetic) DAPK Substrate Peptide chemical structure
  11. BCC6662 Dioctanoylglycol 627-86-1 Dioctanoylglycol chemical structure

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