Intracellular Signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity, as well as normal tissue homeostasis. Errors in signaling interactions and cellular information processing are responsible for diseases such as cancer, autoimmunity, and diabetes. By understanding cell signaling, diseases may be treated more effectively and, theoretically, artificial tissues may be created.
Intracellular Signaling Products Targets
- Cdc25 Phosphatase (2)
- STAT (10)
- PI 3-kinase (22)
- JAK (10)
- PFKFB3 (3)
- Hexokinases (1)
- Protein Kinase G (3)
- NFKB and IKB (30)
- Others (3)
- Cyclooxygenase (24)
- IRAK (1)
- PORCN (4)
- beta-catenin (13)
- PPARγ (16)
- PPARδ (5)
- PPARα (7)
- Inositol Phosphatase (3)
- MYC (1)
- Sphingosine Kinase (2)
- RSK (4)
- Protein Kinase D (3)
- Polo-like Kinase (5)
- Pim Kinase (4)
- PERK (2)
- Phosphoinositide-dependent Kinase 1 (5)
- P21-activated Kinases (2)
- Myosin Light Chain Kinase (4)
- mTOR (14)
- Monopolar Spindle 1 Kinase (2)
- Mnk (2)
- MK2 (2)
- MEK (9)
- LIMK (3)
- Focal Adhesion Kinase (4)
- DNA-Dependent Protein Kinase (6)
- Diacylglycerol Kinase (2)
- Death-Associated Protein Kinase (1)
- Checkpoint Kinase (3)
- Casein Kinase 2 (3)
- Casein Kinase 1 (7)
- Bruton's Tyrosine Kinase (3)
- ATM and ATR Kinase (3)
- Akt (Protein Kinase B) (11)
- Adeonsine Kinase (2)
- Abl Kinase (9)
- Hsp90 (10)
- Hsp70 (4)
- Protein Kinase A (9)
- Protein Kinase C (29)
- Calmodulin-Dependent Kinase (8)
- LRRK2 (4)
- ERK (6)
- DYRK (3)
- Estrogen and Related Receptor (33)
- Tankyrase (5)
- ITK (2)
- ASK1 (2)
- Syk Kinase (4)
- Src Kinase (21)
- Raf Kinase (7)
- IαB Kinase (6)
- p38 MAPK (16)
- Janus N-terminal Kinase (12)
- Androgen Receptor (11)
- Glycogen Synthase Kinase 3 (20)
- AMPK (7)
- Rho-Kinases (9)
- AP-1 (2)
- SREBP (2)
- NUAK (2)
- Telomerase (3)
- Retinoid X Receptor (13)
- Retinoic Acid Receptor (22)
- Proteasome (5)
- Phospholipase (16)
- Lipase (4)
- G Protein (Small) (23)
- Hedgehog Signaling (15)
- DNA Topoisomerase (12)
- DNA, RNA and Protein Synthesis (46)
- Protein Tyrosine Phosphatases (5)
- Protein serine and threonine phosphatase (16)
- Histone Deacetylase (19)
- Aurora Kinase (9)
- Cyclin-Dependent Protein Kinase (21)
Products for Intracellular Signaling - Page 25
- Cat.No. Product Name Information/Activity
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BCC2540
Tazarotene
Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris.
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BCC4874
TTNPB (Arotinoid Acid)
TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
-
BCC7740
BMS 195614
253310-42-8
-
BCC7697
BMS 493
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation.
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BCC7778
CD 2665
CD2665 is a selective RAR-beta/gamma antagonist, with Ki values of 110 nM, 306 nM for RARγ and RARβ, respectively.
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BCC7783
ER 50891
187400-85-7
-
BCC7782
MM 11253
345952-44-5
-
BCC7679
BMS 453
166977-43-1
-
BCC6097
EC 23
EC23 (AGN 190205) is a stable synthetic retinoid analogue and induces neuronal differentiation.
-
BCC1572
Fenretinide
Synthetic retinoid; antiproliferative and antioxidant,Tretinoin, which is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), can induce granulocytic differentiation and apoptosis in acute promyelocytic leukemia (APL) cells.


