Saikosaponin FCAS# 62687-63-2 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 62687-63-2 | SDF | Download SDF |
| PubChem ID | 21598300 | Appearance | Powder |
| Formula | C48H80O17 | M.Wt | 929.14 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (2S,3R,4R,5R,6S)-2-[(2R,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8S,8aS,12aS,14aR,14bR)-8-hydroxy-8a-(hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4,5-dihydroxy-2-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-3-yl]oxy-6-methyloxane-3,4,5-triol | ||
| SMILES | CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3CCC4(C(C3(C)C)CCC5(C4CC=C6C5(CC(C7(C6CC(CC7)(C)C)CO)O)C)C)C)COC8C(C(C(C(O8)CO)O)O)O)O)O)O | ||
| Standard InChIKey | SXILFEBNQCRWAL-VERCZQKXSA-N | ||
| Standard InChI | InChI=1S/C48H80O17/c1-22-31(52)33(54)37(58)41(61-22)65-39-26(20-60-40-36(57)34(55)32(53)25(19-49)62-40)63-42(38(59)35(39)56)64-30-12-13-45(6)27(44(30,4)5)11-14-46(7)28(45)10-9-23-24-17-43(2,3)15-16-48(24,21-50)29(51)18-47(23,46)8/h9,22,24-42,49-59H,10-21H2,1-8H3/t22-,24-,25+,26+,27-,28+,29-,30-,31-,32+,33+,34-,35+,36+,37+,38+,39+,40+,41-,42-,45-,46+,47+,48+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Saikosaponin F shows anti-inflammatory effect against carrageenan-induced plantar oedema in the rat. |
| Targets | Immunology & Inflammation related |
| In vitro | Anti-inflammatory and hepatoprotective activity of saikosaponin f and the root extract of Bupleurum kaoi[Reference: WebLink]Fitoterapia.1994, 65(5): 409-417.A mixture of B. kaoi saponins, containing saikosaponin a, saikosaponin d and Saikosaponin F, showed anti-inflammatory effect against carrageenan-induced plantar oedema in the rat.
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Saikosaponin F Dilution Calculator
Saikosaponin F Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.0763 mL | 5.3813 mL | 10.7626 mL | 21.5253 mL | 26.9066 mL |
| 5 mM | 0.2153 mL | 1.0763 mL | 2.1525 mL | 4.3051 mL | 5.3813 mL |
| 10 mM | 0.1076 mL | 0.5381 mL | 1.0763 mL | 2.1525 mL | 2.6907 mL |
| 50 mM | 0.0215 mL | 0.1076 mL | 0.2153 mL | 0.4305 mL | 0.5381 mL |
| 100 mM | 0.0108 mL | 0.0538 mL | 0.1076 mL | 0.2153 mL | 0.2691 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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[Triterpenoid saponins from Bupleurum marginatum var. stenophyllum].[Pubmed:28879740]
Zhongguo Zhong Yao Za Zhi. 2016 Apr;41(7):1251-1256.
Twelve compounds were obtained by phytochemical investigation of 70% EtOH ( containing 0.5%NH3*H2O )extract of the roots of Bupleurum marginatum var. stenophyllum. Based on comparison of their spectral data, including HR-ESI-MS, (1)H-NMR, (1)(3)C-NMR data, with those of the literature, their structures were elucidated as saikosaponin b2 (1), saikosaponin a(2), saikosaponin b1(3), saikosaponin d (4), hydroxysaikosaponin a (5), saikosaponin b3 (6), saikosaponin c(7),saikosaponin i (8), Saikosaponin F (9), chikusaikosides (10), saikosaponin s (11), and saikosaponin I(12). All compounds belong to olean-type triterpenoid saponin and compounds 1, 3, 5, 8-9,11, and 12 were isolated from this plant for the first time. At a concentration of 20 mumol*L(-)(1), compounds 2, 4, 6, 8, 11 and 12 showed strong inhibition activity against influenza virus WSN33 with the inhibition rate of 91.3%,88.6%,53.4%,61.3%,77.3% and 57.4%,respectively.
[A new saikosaponin from Bupleurum Chinese DC].[Pubmed:11938933]
Yao Xue Xue Bao. 1998;33(1):37-41.
Bupleurum chinese DC. is a well-known and very important traditional Chinese drug. It is often used to treat common cold with fever, alternating chill and fever, the feeling of fullness and oppression in the chest. A new saikosaponin was isolated from Bupleurum chinese DC. and its structure was identified as 3 beta, 16 beta, 28-trihydroxy-11-alpha-methoxy-olean-12-ene-3-O-beta-D-glucosyl-(1-->3)-beta D-fucoside on the basis of chemical and spectral evidence. In addition, six known saikosaponins were isolated and characterized as saikosaponin a, saikosaponin d, saikosaponin c, Saikosaponin F, saikosaponin b3 and saikosaponin b2. All these compounds were isolated from Bupleurum chinese DC. for the first time.
