PalmatrubineCAS# 16176-68-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 16176-68-4 | SDF | Download SDF |
| PubChem ID | 10547386 | Appearance | Powder |
| Formula | C20H20NO4 | M.Wt | 338.38 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 2,3,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-9-ol | ||
| SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)O | ||
| Standard InChIKey | QBUIDYLGKMWNEA-UHFFFAOYSA-O | ||
| Standard InChI | InChI=1S/C20H19NO4/c1-23-17-5-4-12-8-16-14-10-19(25-3)18(24-2)9-13(14)6-7-21(16)11-15(12)20(17)22/h4-5,8-11H,6-7H2,1-3H3/p+1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Palmatrubine binds to double-stranded DNA most probably via an intercalating mode. |
| Structure Identification | Chem Biodivers. 2007 Feb;4(2):145-53.DNA-binding affinities and sequence specificities of protoberberine alkaloids and their demethylated derivatives: a comparative study.[Pubmed: 17311227]
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Palmatrubine Dilution Calculator
Palmatrubine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.9553 mL | 14.7763 mL | 29.5526 mL | 59.1051 mL | 73.8814 mL |
| 5 mM | 0.5911 mL | 2.9553 mL | 5.9105 mL | 11.821 mL | 14.7763 mL |
| 10 mM | 0.2955 mL | 1.4776 mL | 2.9553 mL | 5.9105 mL | 7.3881 mL |
| 50 mM | 0.0591 mL | 0.2955 mL | 0.5911 mL | 1.1821 mL | 1.4776 mL |
| 100 mM | 0.0296 mL | 0.1478 mL | 0.2955 mL | 0.5911 mL | 0.7388 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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DNA-binding affinities and sequence specificities of protoberberine alkaloids and their demethylated derivatives: a comparative study.[Pubmed:17311227]
Chem Biodivers. 2007 Feb;4(2):145-53.
Berberrubine (1a), jatrorubine (2a), and Palmatrubine (3a) have been chemically prepared by partial demethylation of berberine (1), jatrorrhizine (2), and palmatine (3), respectively. Their interactions with calf thymus (CT) DNA, poly(dA-dT)poly(dA-dT), poly(dG-dC)poly(dG-dC), and eight AT-rich 12-mer double-stranded DNAs have been investigated by means of competitive ethidium bromide (EB) displacement experiments. The results showed that DNA-binding affinities of these protoberberine alkaloids have been significantly improved by partial demethylation, and that all of these alkaloids have the preferable binding affinities with AT-rich DNA. Especially, the sequence specificities of DNA-binding of demethylated derivatives 1a, 2a, and 3a had changed to a certain extent when compared with the parent alkaloids 1, 2, and 3, respectively. The binding mode of these alkaloids was further confirmed by UV spectroscopic titration experiments. All the compounds bind to double-stranded DNA most probably via an intercalating mode.
