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12-Oxocalanolide A

CAS# 161753-49-7

12-Oxocalanolide A

Catalog No. BCN4699----Order now to get a substantial discount!

Product Name & Size Price Stock
12-Oxocalanolide A:5mg Please Inquire In Stock
12-Oxocalanolide A:10mg Please Inquire In Stock
12-Oxocalanolide A:20mg Please Inquire In Stock
12-Oxocalanolide A:50mg Please Inquire In Stock

Quality Control of 12-Oxocalanolide A

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Chemical structure

12-Oxocalanolide A

3D structure

Chemical Properties of 12-Oxocalanolide A

Cas No. 161753-49-7 SDF Download SDF
PubChem ID 463613 Appearance Yellow powder
Formula C22H24O5 M.Wt 368.43
Type of Compound Coumarins Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCCC1=CC(=O)OC2=C1C3=C(C=CC(O3)(C)C)C4=C2C(=O)C(C(O4)C)C
Standard InChIKey HQVBDUZROQMWRN-VXGBXAGGSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of 12-Oxocalanolide A

The herbs of Calophyllum polyanthum

Biological Activity of 12-Oxocalanolide A

Description1. 12-Oxocalanolide A is an inhibitor of HIV-1 reverse transcriptase (RT) and exhibits activity against a variety of viruse selected for resistance to other HIV-1 nonnucleoside RT inhibitors.
TargetsHIV

12-Oxocalanolide A Dilution Calculator

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12-Oxocalanolide A Molarity Calculator

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Preparing Stock Solutions of 12-Oxocalanolide A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.7142 mL 13.5711 mL 27.1422 mL 54.2844 mL 67.8555 mL
5 mM 0.5428 mL 2.7142 mL 5.4284 mL 10.8569 mL 13.5711 mL
10 mM 0.2714 mL 1.3571 mL 2.7142 mL 5.4284 mL 6.7855 mL
50 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.0857 mL 1.3571 mL
100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5428 mL 0.6786 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on 12-Oxocalanolide A

Quantification of (+)-calanolide A, a novel and naturally occurring anti-HIV agent, by high-performance liquid chromatography in plasma from rat, dog and human.[Pubmed:10901131]

J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):267-75.

A HPLC method was validated for quantification of (+)-calanolide A (1), a novel anti-HIV agent, in rat, dog and human plasma. The synthetic intermediate (+/-)-12-Oxocalanolide A (2) was found to be a suitable internal standard. Compounds were extracted from plasma using a solid-phase C(18) cartridge and quantified over the assay range of 12.5 to 800 ng/ml. The method was utilized to determine (+)-calanolide A pharmacokinetics in rats, dogs and humans. This is the first report of a validated HPLC assay for determination of (+)-calanolide A concentrations in rat and dog plasma as well as human plasma obtained from clinical trials. There was no evidence of in vivo epimerization of (+)-calanolide A to its inactive epimer (+)-calanolide B (3).

In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI.[Pubmed:9873509]

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2179-84.

The three chromanone derivatives, (+)-, (-)-, and (+/-)-12-Oxocalanolide A (2), were evaluated for in vitro antiviral activities against HIV and simian immunodeficiency virus (SIV). The compounds were determined to be inhibitors of HIV-1 reverse transcriptase (RT) and exhibited activity against a variety of viruses selected for resistance to other HIV-1 nonnucleoside RT inhibitors. They are the first reported calanolide analogues capable of inhibiting SIV.

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