LeptomerineCAS# 22048-97-1 |
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| Cas No. | 22048-97-1 | SDF | Download SDF |
| PubChem ID | 10856530 | Appearance | Powder |
| Formula | C13H15NO | M.Wt | 201.3 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Synonyms | N-methyl-2-propyl-4-quinolone | ||
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | 1-methyl-2-propylquinolin-4-one | ||
| SMILES | CCCC1=CC(=O)C2=CC=CC=C2N1C | ||
| Standard InChIKey | HHCLDHNLTJDYEN-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C13H15NO/c1-3-6-10-9-13(15)11-7-4-5-8-12(11)14(10)2/h4-5,7-9H,3,6H2,1-2H3 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The herbs of Haplophyllum leptomerum
| Description | 1. Leptomerine (IC₅₀ = 2.5 mM) shows potent anticholinesterasic activity. |
| Targets | AChR |
Leptomerine Dilution Calculator
Leptomerine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.9677 mL | 24.8385 mL | 49.6771 mL | 99.3542 mL | 124.1927 mL |
| 5 mM | 0.9935 mL | 4.9677 mL | 9.9354 mL | 19.8708 mL | 24.8385 mL |
| 10 mM | 0.4968 mL | 2.4839 mL | 4.9677 mL | 9.9354 mL | 12.4193 mL |
| 50 mM | 0.0994 mL | 0.4968 mL | 0.9935 mL | 1.9871 mL | 2.4839 mL |
| 100 mM | 0.0497 mL | 0.2484 mL | 0.4968 mL | 0.9935 mL | 1.2419 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease.[Pubmed:21160449]
Molecules. 2010 Dec 13;15(12):9205-13.
Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guaranta, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, Leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid Leptomerine showed the highest activity (IC(5)(0) = 2.5 mM), similar to that of the reference compound galanthamine (IC(5)(0) = 1.7 mM). The results showed for the first time the presence of alkaloids Leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.
Leptomerine, an alkaloid from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer Disease. Leptomerine inhibits acetyl cholinesterase (AChE) with an IC50 of 2.5 μM. Anticholinesterasic activity.
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