Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 70

  1. Cat.No. Product Name Information/Activity
  2. BCC1239 VU 0364439 VU 0364439 is a mGlu4 positive allosteric modulator (PAM), with EC50 of 19.8 nM. VU 0364439 chemical structure
  3. BCC4597 VU 0364770 VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively. VU 0364770 chemical structure
  4. BCC7796 (±)-PPCC oxalate 932736-91-9 (±)-PPCC oxalate chemical structure
  5. BCC6339 SA 4503 dihydrochloride Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. SA 4503 dihydrochloride chemical structure
  6. BCC6928 (+)-SK&F 10047 hydrochloride 133005-41-1 (+)-SK&F 10047 hydrochloride chemical structure
  7. BCC6863 BD 1047 dihydrobromide BD-1047 (dihydrobromide) is a selective functional antagonist of sigma-1 receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia. BD 1047 dihydrobromide chemical structure
  8. BCC7573 NE 100 hydrochloride 149409-57-4 NE 100 hydrochloride chemical structure
  9. BCC6832 BD 1063 dihydrochloride BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist. BD 1063 dihydrochloride chemical structure
  10. BCC4697 Pentoxyverine Citrate Pentoxyverine Citrate is an antitussive (cough suppressant) commonly used for cough associated with illnesses like common cold. Pentoxyverine Citrate chemical structure
  11. BCC1215 Fluvoxamine maleate Fluvoxamine maleate (DU-23000 maleate) is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Fluvoxamine maleate chemical structure

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