Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 60

  1. Cat.No. Product Name Information/Activity
  2. BCC7862 CIQ CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. CIQ chemical structure
  3. BCC2946 H-Gly-OH Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. H-Gly-OH chemical structure
  4. BCC5888 MNI-caged-NMDA 1227675-52-6 MNI-caged-NMDA chemical structure
  5. BCC7292 N20C hydrochloride 1177583-87-7 N20C hydrochloride chemical structure
  6. BCC4504 Nefiracetam Nefiracetam is a GABAergic, cholinergic, and monoaminergic neuronal systems enhancer for Ro 5-4864-induced convulsions. Nefiracetam chemical structure
  7. BCC2676 H-D-Ser-OH (R)-Serine, an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. (R)-Serine has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration. H-D-Ser-OH chemical structure
  8. BCC6864 Spermine tetrahydrochloride Spermine tetrahydrochloride is an endogenous metabolite. Spermine tetrahydrochloride chemical structure
  9. BCC6590 (1S,3R)-ACPD 111900-32-4 (1S,3R)-ACPD chemical structure
  10. BCC6567 (±)-trans-ACPD trans-ACPD, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons. (±)-trans-ACPD chemical structure
  11. BCC6910 CHPG CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. CHPG chemical structure

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