Schizophrenia Research

Schizophrenia is a chronic, debilitating mental disorder affecting 1-2% of the global population. Symptoms are split into two types; 'positive' symptoms, including delusions and hallucinations, and 'negative' symptoms, including anhedonia and lack of motivation. Studies suggest that genetics, early environment, neurobiology, psychological and social processes are important contributory factors; some recreational and prescription drugs appear to cause or worsen symptoms. Several neurobiological alterations in brain structure, physiology and neurochemistry have been documented, along with an ever-increasing list of susceptibility genes.

Schizophrenia Research Products Targets

Products for Schizophrenia Research - Page 62

  1. Cat.No. Product Name Information/Activity
  2. BCC6607 (S)-3-Carboxy-4-hydroxyphenylglycine 55136-48-6 (S)-3-Carboxy-4-hydroxyphenylglycine chemical structure
  3. BCC6600 (S)-4-Carboxy-3-hydroxyphenylglycine 85148-82-9 (S)-4-Carboxy-3-hydroxyphenylglycine chemical structure
  4. BCC6603 (S)-4-Carboxyphenylglycine 134052-73-6 (S)-4-Carboxyphenylglycine chemical structure
  5. BCC6896 CPCCOEt 179067-99-3 CPCCOEt chemical structure
  6. BCC6888 E4CPG E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG . E4CPG chemical structure
  7. BCC7345 Fenobam Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity. Fenobam chemical structure
  8. BCC7166 HexylHIBO 334887-43-3 HexylHIBO chemical structure
  9. BCC7167 (S)-HexylHIBO 334887-48-8 (S)-HexylHIBO chemical structure
  10. BCC7332 JNJ 16259685 JNJ16259685 is a selective antagonist of mGlu1 receptor, and inhibits the synaptic activation of mGlu1 in a concentration-dependent manner with IC50 of 19 nM. JNJ 16259685 chemical structure
  11. BCC6983 LY 367385 LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a. LY367385 has neuroprotective, anticonvulsant and antiepileptic effects. LY 367385 chemical structure

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